UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Recent TB transmission, clustering and predictors of large clusters in London, 2010-2012: results from first 3 years of universal MIRU-VNTR strain typing

Hamblion, EL; Le Menach, A; Anderson, LF; Lalor, MK; Brown, T; Abubakar, I; Anderson, C; ... Anderson, SR; + view all (2016) Recent TB transmission, clustering and predictors of large clusters in London, 2010-2012: results from first 3 years of universal MIRU-VNTR strain typing. Thorax , 71 (8) pp. 749-756. 10.1136/thoraxjnl-2014-206608. Green open access

[thumbnail of abubakar_Thorax-2016-Hamblion-749-56.pdf]
Preview
Text
abubakar_Thorax-2016-Hamblion-749-56.pdf

Download (516kB) | Preview

Abstract

BACKGROUND: The incidence of TB has doubled in the last 20 years in London. A better understanding of risk groups for recent transmission is required to effectively target interventions. We investigated the molecular epidemiological characteristics of TB cases to estimate the proportion of cases due to recent transmission, and identify predictors for belonging to a cluster. METHODS: The study population included all culture-positive TB cases in London residents, notified between January 2010 and December 2012, strain typed using 24-loci multiple interspersed repetitive units-variable number tandem repeats. Multivariable logistic regression analysis was performed to assess the risk factors for clustering using sociodemographic and clinical characteristics of cases and for cluster size based on the characteristics of the first two cases. RESULTS: There were 10 147 cases of which 5728 (57%) were culture confirmed and 4790 isolates (84%) were typed. 2194 (46%) were clustered in 570 clusters, and the estimated proportion attributable to recent transmission was 34%. Clustered cases were more likely to be UK born, have pulmonary TB, a previous diagnosis, a history of substance abuse or alcohol abuse and imprisonment, be of white, Indian, black-African or Caribbean ethnicity. The time between notification of the first two cases was more likely to be <90 days in large clusters. CONCLUSIONS: Up to a third of TB cases in London may be due to recent transmission. Resources should be directed to the timely investigation of clusters involving cases with risk factors, particularly those with a short period between the first two cases, to interrupt onward transmission of TB.

Type: Article
Title: Recent TB transmission, clustering and predictors of large clusters in London, 2010-2012: results from first 3 years of universal MIRU-VNTR strain typing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/thoraxjnl-2014-206608
Publisher version: http://doi.org/10.1136/thoraxjnl-2014-206608
Language: English
Additional information: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Respiratory System, MYCOBACTERIUM-TUBERCULOSIS, MOLECULAR EPIDEMIOLOGY, SURVEILLANCE, NETHERLANDS, POPULATION, NATIONWIDE, OUTBREAK, UK
UCL classification: UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1508380
Downloads since deposit
79Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item