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A comparative reference study for the validation of HLA-matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units

Bochtler, W; Gragert, L; Patel, ZI; Robinson, J; Steiner, D; Hofmann, JA; Pingel, J; ... Mueller, CR; + view all (2016) A comparative reference study for the validation of HLA-matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units. HLA , 87 (6) pp. 439-448. 10.1111/tan.12817. Green open access

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Abstract

The accuracy of human leukocyte antigen (HLA)-matching algorithms is a prerequisite for the correct and efficient identification of optimal unrelated donors for patients requiring hematopoietic stem cell transplantation. The goal of this World Marrow Donor Association study was to validate established matching algorithms from different international donor registries by challenging them with simulated input data and subsequently comparing the output. This experiment addressed three specific aspects of HLA matching using different data sets for tasks of increasing complexity. The first two tasks targeted the traditional matching approach identifying discrepancies between patient and donor HLA genotypes by counting antigen and allele differences. Contemporary matching procedures predicting the probability for HLA identity using haplotype frequencies were addressed by the third task. In each task, the identified disparities between the results of the participating computer programs were analyzed, classified and quantified. This study led to a deep understanding of the algorithms participating and finally produced virtually identical results. The unresolved discrepancies total to less than 1%, 4% and 2% for the three tasks and are mostly because of individual decisions in the design of the programs. Based on these findings, reference results for the three input data sets were compiled that can be used to validate future matching algorithms and thus improve the quality of the global donor search process.

Type: Article
Title: A comparative reference study for the validation of HLA-matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/tan.12817
Publisher version: http://dx.doi.org/10.1111/tan.12817
Language: English
Additional information: Copyright © 2016 The Authors. HLA published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Further supporting information is available at http://onlinelibrary.wiley.com/wol1/doi/10.1111/tan.12817/suppinfo
Keywords: Science & Technology, Life Sciences & Biomedicine, Cell Biology, Immunology, Pathology, donor registry, hematopoietic stem cell transplantation, human leukocyte antigen, immunogenetics, matching algorithm, patient-donor matching, Unrelated Donors, Transplantation, Guidelines, Registries, Exchange, Nomenclature, Association, Haplotypes, Diversity, Standards
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1507985
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