Goyanes, A;
Kobayashi, M;
Martínez-Pacheco, R;
Gaisford, S;
Basit, A;
(2016)
Fused-filament 3D printing of drug products: Microstructure analysis and drug release characteristics of PVA-based caplets.
International Journal of Pharmaceutics
, 514
(1)
pp. 290-295.
10.1016/j.ijpharm.2016.06.021.
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Abstract
Fused deposition modeling (FDM) 3–Dimensional (3D) printing is becoming an increasingly popular technology in the pharmaceutical field, since it allows the manufacture of personalized oral dosage forms by deposition of thin layers of material. Here, a filament extruder was used to obtain filaments of polyvinyl alcohol (PVA) containing paracetamol or caffeine appropriate for 3D printing. The filaments were used to manufacture caplets for oral administration by FDM 3D printing in order to evaluate the effect of the internal structure (micropore volume), drug loading and composition on drug dissolution behaviour. Micropore volume of the caplets was primarily determined by the presence of large pores due to gaps in the printed layers/net while printing, and the porosity of the caplets was 10 fold higher than the porosity of the extruded filament. Dynamic dissolution drug release tests on the caplets in biorelevant bicarbonate media revealed distinctive release profiles, which were dependent on drug solubility and drug loading. Porosity of the caplets did not help to predict the different drug release profiles. This study confirms the potential of 3D printing to fabricate caplets and helps to elucidate which factors influence drug release from this type of new dosage forms.
| Type: | Article |
|---|---|
| Title: | Fused-filament 3D printing of drug products: Microstructure analysis and drug release characteristics of PVA-based caplets |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijpharm.2016.06.021 |
| Publisher version: | https://doi.org/10.1016/j.ijpharm.2016.06.021 |
| Language: | English |
| Additional information: | Copyright © 2016. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. |
| Keywords: | Three dimensional printing; fused deposition modeling; acetaminophen; hot melt extrusion; bicarbonate buffers; rapid prototyping; additive manufacturing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1507794 |
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