Brunker, J;
Beard, P;
(2016)
Velocity measurements in whole blood using acoustic resolution photoacoustic Doppler.
Biomedical Optics Express
, 7
(7)
pp. 2789-2806.
10.1364/BOE.7.002789.
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Abstract
Acoustic resolution photoacoustic Doppler velocimetry promises to overcome the spatial resolution and depth penetration limitations of current blood flow measuring methods. Despite successful implementation using blood-mimicking fluids, measurements in blood have proved challenging, thus preventing in vivo application. A common explanation for this difficulty is that whole blood is insufficiently heterogeneous relative to detector frequencies of tens of MHz compatible with deep tissue photoacoustic measurements. Through rigorous experimental measurements we provide new insight that refutes this assertion. We show for the first time that, by careful choice of the detector frequency and field-of-view, and by employing novel signal processing methods, it is possible to make velocity measurements in whole blood using transducers with frequencies in the tens of MHz range. These findings have important implications for the prospects of making deep tissue measurements of blood flow relevant to the study of microcirculatory abnormalities associated with cancer, diabetes, atherosclerosis and other conditions.
| Type: | Article |
|---|---|
| Title: | Velocity measurements in whole blood using acoustic resolution photoacoustic Doppler |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/BOE.7.002789 |
| Publisher version: | http://dx.doi.org/10.1364/BOE.7.002789 |
| Language: | English |
| Additional information: | Copyright Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemical Research Methods, Optics, Radiology, Nuclear Medicine & Medical Imaging, Biochemistry & Molecular Biology, IN-VIVO, CORRELATION SPECTROSCOPY, CROSS-CORRELATION, FLOW, MICROSCOPY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1506134 |
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