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Dendritic cells in remodeling of lymph nodes during immune responses

Acton, SE; Reis e Sousa, C; (2016) Dendritic cells in remodeling of lymph nodes during immune responses. Immunological Reviews , 271 (1) pp. 221-229. 10.1111/imr.12414. Green open access

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Abstract

A critical hallmark of adaptive immune responses is the rapid and extensive expansion of lymph nodes. During this process, the complex internal structure of the organs is maintained revealing the existence of mechanisms able to balance lymph node integrity with structural flexibility. This article reviews the extensive architectural remodeling that occurs within lymph nodes during adaptive immune responses and how it is regulated by dendritic cells (DCs). In particular we focus on previously unappreciated functions of DCs in coordinating remodeling of lymph node vasculature, expansion of the fibroblastic reticular network and maintenance of lymphoid stromal phenotypes. Our increased understanding of these processes indicates that DCs need to be viewed not only as key antigen-presenting cells for lymphocytes but also as broad-acting immune sentinels that convey signals to lymphoid organ stroma and thereby facilitate immune response initiation at multiple levels.

Type: Article
Title: Dendritic cells in remodeling of lymph nodes during immune responses
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/imr.12414
Publisher version: http://dx.doi.org/10.1111/imr.12414
Language: English
Additional information: Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: [Acton, S. E. and Reis e Sousa, C. (2016), Dendritic cells in remodeling of lymph nodes during immune responses. Immunological Reviews, 271: 221–229. doi: 10.1111/imr.12414], which has been published in final form at http://dx.doi.org/10.1111/imr.12414. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: lymph node; inflammation;stroma; dendritic cells; fibroblastic reticular cells; high endothelial venule
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1505869
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