Richardson, JP;
Chan, CH;
Blanc, J;
Saadi, M;
Macmillan, D;
(2010)
Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N -> S acyl transfer.
ORG BIOMOL CHEM
, 8
(6)
1351 - 1360.
10.1039/b920535g.
Abstract
Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.
| Type: | Article |
|---|---|
| Title: | Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N -> S acyl transfer |
| DOI: | 10.1039/b920535g |
| Keywords: | X-RAY-STRUCTURE, GLYCOPROTEIN-SYNTHESIS, CHEMOENZYMATIC SYNTHESIS, EXPRESSED PROTEIN, N-GLYCANS, SEMISYNTHESIS, ERYTHROPOIETIN, GLYCOPEPTIDES, CHEMISTRY, LIGANDS |
| URI: | http://discovery.ucl.ac.uk/id/eprint/150470 |
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