Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N -> S acyl transfer.
ORG BIOMOL CHEM
1351 - 1360.
Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.
|Title:||Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N -> S acyl transfer|
|Keywords:||X-RAY-STRUCTURE, GLYCOPROTEIN-SYNTHESIS, CHEMOENZYMATIC SYNTHESIS, EXPRESSED PROTEIN, N-GLYCANS, SEMISYNTHESIS, ERYTHROPOIETIN, GLYCOPEPTIDES, CHEMISTRY, LIGANDS|
|UCL classification:||UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Maths and Physical Sciences
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