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Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N -> S acyl transfer

Richardson, JP; Chan, CH; Blanc, J; Saadi, M; Macmillan, D; (2010) Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N -> S acyl transfer. ORG BIOMOL CHEM , 8 (6) 1351 - 1360. 10.1039/b920535g.

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Abstract

Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.

Type:Article
Title:Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N -> S acyl transfer
DOI:10.1039/b920535g
Keywords:X-RAY-STRUCTURE, GLYCOPROTEIN-SYNTHESIS, CHEMOENZYMATIC SYNTHESIS, EXPRESSED PROTEIN, N-GLYCANS, SEMISYNTHESIS, ERYTHROPOIETIN, GLYCOPEPTIDES, CHEMISTRY, LIGANDS
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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