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Cardiac vagal preganglionic neurones: An update

Gourine, AV; Machhada, A; Trapp, S; Spyer, KM; (2016) Cardiac vagal preganglionic neurones: An update. Autonomic Neuroscience , 199 pp. 24-28. 10.1016/j.autneu.2016.06.003. Green open access

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Abstract

The autonomic nervous system controls the heart by dynamic recruitment and withdrawal of cardiac parasympathetic and sympathetic activities. These activities are generated by groups of sympathoexcitatory and vagal preganglionic neurones residing in a close proximity to each other within well-defined structures of the brainstem. This short essay provides a general overview and an update on the latest developments in our understanding of the central nervous origins and functional significance of cardiac vagal tone. Significant experimental evidence suggests that distinct groups of cardiac vagal preganglionic neurones with different patterns of activity control nodal tissue (controlling the heart rate and atrioventricular conductance) and the ventricular myocardium (modulating its contractility and excitability).

Type: Article
Title: Cardiac vagal preganglionic neurones: An update
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.autneu.2016.06.003
Publisher version: https://doi.org/10.1016/j.autneu.2016.06.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Atrioventricular conductance; Contractility; Excitability; Left ventricle; Parasympathetic; Vagal preganglionic neurones
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1504613
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