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Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods

Hirano, K; Macmillan, D; Tezuka, K; Tsuji, T; Kajihara, Y; (2009) Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods. ANGEW CHEM INT EDIT , 48 (50) 9557 - 9560. 10.1002/anie.200904376.

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Type:Article
Title:Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods
DOI:10.1002/anie.200904376
Keywords:erythropoietin, glycopeptides, glycoproteins, native chemical ligation, protein expression, HAMSTER OVARY CELLS, RECOMBINANT-HUMAN-ERYTHROPOIETIN, CHEMOENZYMATIC SYNTHESIS, GLYCOPROTEIN-SYNTHESIS, THERAPEUTIC PROTEINS, CONVENIENT SYNTHESIS, LIGATION, GLYCOSYLATION, SEMISYNTHESIS, INTACT
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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