Ban, HY;
Schweiger, MJ;
Kavuri, VC;
Cochran, JM;
Xie, L;
Busch, D;
Katrašnik, J;
... Yodh, AG; + view all
(2016)
Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry.
Medical Physics
, 43
(7)
pp. 4383-4395.
10.1118/1.4953830.
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Abstract
Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source–detector pairs (106). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.
| Type: | Article |
|---|---|
| Title: | Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1118/1.4953830 |
| Publisher version: | http://dx.doi.org/10.1118/1.4953830 |
| Language: | English |
| Additional information: | Copyright © 2016 American Association of Physicists in Medicine. All rights reserved. |
| Keywords: | Diffuse optical tomography, optical mammography, breast cancer imaging, CCD-based optical tomography instrumentation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1503983 |
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