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One Face of Chlamydia trachomatis: The Infectious Elementary Body

Cossé, MM; Hayward, RD; Subtil, A; (2016) One Face of Chlamydia trachomatis: The Infectious Elementary Body. In: Current Topics in Microbiology and Immunology. (pp. 1-24). Springer Berlin Heidelberg

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Abstract

The lifestyle of Chlamydiae is unique: the bacteria alternate between two morphologically distinct forms, an infectious non-replicative elementary body (EB), and a replicative, non-infectious reticulate body (RB). This review focuses on recent advances in understanding the structure and function of the infectious form of the best-studied member of the phylum, the human pathogen Chlamydia trachomatis. Once considered as an inert particle of little functional capacity, the EB is now perceived as a sophisticated entity that encounters at least three different environments during each infectious cycle. We review current knowledge on its composition and morphology, and emerging metabolic activities. These features confer resistance to the extracellular environment, the ability to penetrate a host cell and ultimately enable the EB to establish a niche enabling bacterial survival and growth. The bacterial and host molecules involved in these processes are beginning to emerge.

Type: Book chapter
Title: One Face of Chlamydia trachomatis: The Infectious Elementary Body
Location: Germany
DOI: 10.1007/82_2016_12
Publisher version: http://doi.org/10.1007/82_2016_12
Language: English
Additional information: Copyright © 2017 Springer Berlin Heidelberg. Springer International Publishing Switzerland. All rights reserved.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1503335
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