UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation

Moser, C; Pohl, G; Haslinger, I; Knapp, S; Rowczenio, D; Russel, T; Lachmann, HJ; ... Kovarik, J; + view all (2009) Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation. NEPHROL DIAL TRANSPL , 24 (2) 676 - 678. 10.1093/ndt/gfn646.

Full text not available from this repository.

Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of fever and inflammation. The most severe complication of FMF is the development of AA amyloidosis, which can be life threatening. The only current effective treatment for FMF is colchicine. Regular prophylactic treatment with colchicine at a dose of 1-2 mg daily prevents or substantially reduces the clinical manifestations of FMF in at least 90% of cases. However, similar to 10% of patients are reported to be resistant or non-responsive to colchicine and in these cases there is no consensus as to which second line agents should be used. We describe the first case, to our knowledge, of a patient with FMF and end-stage renal failure due to AA amyloidosis, successfully treated with IL-1 receptor blockade. Our data suggest that the IL-1 receptor antagonist Anakinra (Kineret((R)); r-metHuIL-1 ra) may represent a safe and effective therapy for the treatment of colchicine-resistant FMF, in patients requiring renal replacement therapy, with dialysis or transplantation.

Type: Article
Title: Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation
DOI: 10.1093/ndt/gfn646
Keywords: MUTATIONS, PROTEIN, MEFV
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/150212
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item