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3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters

Kang, J; Richardson, JP; Macmillan, D; (2009) 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters. CHEM COMMUN (4) 407 - 409. 10.1039/b815888f.

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Abstract

Peptides and proteins fragment sequence-specifically in the presence of 3-mercaptopropionic acid to afford thioesters which can be used in native chemical ligation reactions.

Type: Article
Title: 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters
DOI: 10.1039/b815888f
Keywords: NATIVE CHEMICAL LIGATION, SOLID-PHASE SYNTHESIS, C-TERMINAL THIOESTERS, FMOC-BASED SYNTHESIS, ALPHA-THIOESTERS, THIOESTERIFICATION, GENERATION, STRATEGIES, FACILE, SHIFT
UCL classification: UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/150208
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