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Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members.

Tsioupra, K; West, LF; Davis, MB; Parrington, JM; Delhanty, JD; (1988) Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members. Dis Markers , 6 (2) pp. 127-132.

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Abstract

Detailed chromosome analysis failed to reveal any evidence for spontaneous chromosome instability in lymphocytes from patients with multiple endocrine neoplasia, type 2 (MEN-2), whereas, with one exception, lymphocytes from MEN-2 patients were significantly more sensitive to chromosome damage by bleomycin and, to a lesser extent, MNNG than those from controls. The exceptional case suggests possible genetic heterogeneity in MEN-2.

Type: Article
Title: Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members.
Location: United States
Keywords: Adult, Bleomycin, Carcinoma, Chromosome Aberrations, Humans, Lymphocytes, Methylnitronitrosoguanidine, Multiple Endocrine Neoplasia, Thyroid Neoplasms
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Reproductive Health
URI: http://discovery.ucl.ac.uk/id/eprint/1501718
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