Lees, JG;
Dawson, NL;
Sillitoe, I;
Orengo, CA;
(2016)
Functional innovation from changes in protein domains and their combinations.
Current Opinion in Structural Biology
, 38
pp. 44-52.
10.1016/j.sbi.2016.05.016.
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Abstract
Domains are the functional building blocks of proteins. In this work we discuss how domains can contribute to the evolution of new functions. Domains themselves can evolve through various mechanisms, altering their intrinsic function. Domains can also facilitate functional innovations by combining with other domains to make novel proteins. We discuss the mechanisms by which domain and domain combinations support functional innovations. We highlight interesting examples where changes in domain combination promote changes at the domain level.
| Type: | Article |
|---|---|
| Title: | Functional innovation from changes in protein domains and their combinations |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.sbi.2016.05.016 |
| Publisher version: | http://doi.org/10.1016/j.sbi.2016.05.016 |
| Language: | English |
| Additional information: | © 2016 Elsevier Ltd. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, Genome Evolution, Gene Fusions, Large-scale, Superfamilies, Architecture, Robustness, Database, Classification, Mechanisms, Plasticity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1501341 |
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