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Advances in Scalable Implantable Systems for Neurostimulation Using Networked ASICs

Liu, X; Zong, Z; Jiang, D; Bougaila, B; Donaldson, N; Demosthenous, A; (2016) Advances in Scalable Implantable Systems for Neurostimulation Using Networked ASICs. IEEE Design and Test , 33 (4) pp. 8-23. 10.1109/MDAT.2016.2533358. Green open access

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Abstract

Neurostimulation is a known method for restoring lost functions to neurologically impaired patients. This paper describes recent advances in scalable implantable stimulation systems using networked application specific integrated circuits (ASICs). It discusses how they can meet the ever-growing demand for high-density neural interfacing and long-term reliability. A detailed design example of an implantable (inductively linked) scalable stimulation system for restoring lower limb functions in paraplegics after spinal cord injury is presented. It comprises a central hub implanted at the costal margin and multiple Active Books which provide the interface for stimulating nerve roots in the cauda equina. A 16-channel stimulation system using four Active Books is demonstrated. Each Active Book has an embedded ASIC, which is responsible for initiating stimulus current to the electrodes. It also ensures device safety by monitoring temperature, humidity, and peak electrode voltage during stimulation. The implant hub was implemented using a microcontroller-based circuit. The ASIC in the Active Book was fabricated using XFAB’s 0.6-µm high-voltage CMOS process. The stimulation system does not require an accurate reference clock in the implant. Measured results are provided.

Type: Article
Title: Advances in Scalable Implantable Systems for Neurostimulation Using Networked ASICs
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/MDAT.2016.2533358
Publisher version: http://dx.doi.org/10.1109/MDAT.2016.2533358
Language: English
Additional information: © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works
Keywords: Active Books, humidity measurement, implantable stimulator, low power, networked ASICs, neurostimulation, reliability, scalable stimulation system, temperature measurement.
URI: http://discovery.ucl.ac.uk/id/eprint/1501034
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