UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Schizophrenia with onset at the extremes of adult life

Castle, DJ; Wessely, S; Howard, R; Murray, RM; (1997) Schizophrenia with onset at the extremes of adult life. International Journal of Geriatric Psychiatry , 12 (7) pp. 712-717. 10.1002/(SICI)1099-1166(199707)12:7<712::AID-GPS601>3.0.CO;2-5.

Full text not available from this repository.

Abstract

Objective. To define the epidemiology, phenomenology, premorbid and risk factors in patients with the first manifestation of a schizophrenia-like illness after the age of 60 years, and compare them with patients with an onset before the age of 25 years. Design/setting/subjects. All contacts for a non-affective psychotic illness across all ages of onset were ascertained through a psychiatric case register; patients were rediagnosed according to operationalized criteria for psychotic illness, and those with a very early and very late onset compared. Main outcomes measures. Phenomenological, premorbid and aetiological parameters were compared in the two groups, using risk ratios and 95% confidence intervals. Results. Very late onset patients (N = 72) were, compared to their very early onset counterparts (N = 192), more likely to be female, have good premorbid functioning and developmental history, and to exhibit persecutory delusions and hallucinations; they were less likely to have negative schizophrenic symptoms, to have a positive family history of schizophrenia, or have suffered pregnancy or birth complications. Conclusions. The results highlight premorbid, aetiological and phenomenological differences between patients with the onset of a schizophrenia-like illness at the extremes of adult life, and suggest it is premature to consider the two groups to be merely different manifestations of the same illness.

Type: Article
Title: Schizophrenia with onset at the extremes of adult life
DOI: 10.1002/(SICI)1099-1166(199707)12:7<712::AID-GPS601>3.0.CO;2-5
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/1500805
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item