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99Tcm-HMPAO SPET and cerebral blood flow: a study of CO2 reactivity.

Choksey, MS; Costa, DC; Iannotti, F; Ell, PJ; Crockard, HA; (1989) 99Tcm-HMPAO SPET and cerebral blood flow: a study of CO2 reactivity. Nucl Med Commun , 10 (8) pp. 609-618.

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Abstract

Single photon emission tomography (SPET) studies using 99Tcm-HMPAO are in widespread use in the functional imaging of cerebral blood flow (CBF). While qualitatively the images correlate well with other imaging modalities, there are doubts as to the quantitative accuracy of this method. In particular, the uptake and subsequent retention of 99Tcm-HMPAO in conditions of high flow is known to be nonlinear. In this study, we compared the quantitative retention of 99Tcm-HMPAO in eight subjects under conditions of normo- and hypercapnia. There was no significant increase, despite a mean rise of the end tidal pCO2 from 5.06 to 7.06 kPa, a stimulus that is known to provoke an 80-100% rise in CBF. We conclude that SPET studies with 99Tcm-HMPAO provide excellent qualitative images of the distribution of CBF, but that quantitative data in ml hg-1 min-1 must be interpreted with caution.

Type: Article
Title: 99Tcm-HMPAO SPET and cerebral blood flow: a study of CO2 reactivity.
Location: England
Keywords: Adult, Aged, Blood-Brain Barrier, Carbon Dioxide, Cerebrovascular Circulation, False Positive Reactions, Female, Humans, Hypercapnia, Male, Middle Aged, Organotechnetium Compounds, Oximes, Partial Pressure, Technetium Tc 99m Exametazime, Tomography, Emission-Computed, Single-Photon
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
URI: http://discovery.ucl.ac.uk/id/eprint/1500104
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