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Dopaminergic effects on electrophysiological and functional MRI measures of human cortical stimulus-response power laws.

Arthurs, OJ; Stephenson, CME; Rice, K; Lupson, VC; Spiegelhalter, DJ; Boniface, SJ; Bullmore, ET; (2004) Dopaminergic effects on electrophysiological and functional MRI measures of human cortical stimulus-response power laws. Neuroimage , 21 (2) pp. 540-546. 10.1016/j.neuroimage.2003.09.067.

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Abstract

Power laws have been widely used to formulate relationships between objective intensity of stimulation and subjective intensity of sensation. We investigated the effects of dopaminergic drug treatment (sulpiride) on the relationship between somatosensory stimulus intensity and cortical response measured electrophysiologically by somatosensory-evoked potentials (SEP) and functional magnetic resonance imaging (fMRI). The intensity of stimulation was related by a simple power law to both electrophysiological and fMRI measures of cortical response, with overlapping confidence intervals for both power law exponents. Sulpiride did not modulate the power law exponent, but significantly attenuated the "gain" of both stimulus-response functions. Using path analysis we decomposed dopaminergic effects on fMRI data into an indirect component (16%), predictable by drug effects on SEP, and a direct component (84%), not explained electrophysiologically. Results indicate that sulpiride has comparable effects on power law parameters estimated from SEP and fMRI, but fMRI has superior sensitivity to detect drug effects on somatosensory cortical recruitment by graded stimulation.

Type: Article
Title: Dopaminergic effects on electrophysiological and functional MRI measures of human cortical stimulus-response power laws.
Location: United States
DOI: 10.1016/j.neuroimage.2003.09.067
Keywords: Adult, Afferent Pathways, Brain Mapping, Confidence Intervals, Dopamine Antagonists, Electric Stimulation, Electroencephalography, Evoked Potentials, Somatosensory, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mathematical Computing, Median Nerve, Middle Aged, Recruitment, Neurophysiological, Sensory Thresholds, Somatosensory Cortex, Sulpiride, Synaptic Transmission
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1499788
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