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Sympathetic innervation of the kidney in health and disease: Emphasis on the role of purinergic cotransmission

Burnstock, G; Loesch, A; (2016) Sympathetic innervation of the kidney in health and disease: Emphasis on the role of purinergic cotransmission. Autonomic Neuroscience , 204 pp. 4-16. 10.1016/j.autneu.2016.05.007. Green open access

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Abstract

There is introductory information about non-synaptic transmission at sympathetic neuroeffector junctions and sympathetic nerve cotransmission utilizing noradrenaline and ATP as cotransmitters. Then the organzation and location of sympathetic nerves in different sites in the kidney are described, including renal arteries, juxtaglomerular arterioles and renal tubules. Sympathetic nervous control of glomerular filtration rate and of renin secretion are discussed. Evidence, obtained largely from experiments on animals, for sympathetic nerve modulation of the transport of water, sodium and other ions in the collecting duct of the nephron is described. Finally, there is coverage of the roles of sympathetic nerves in renal diseases, including hypertension, diabetes, hypothyroidism and ischaemia.

Type: Article
Title: Sympathetic innervation of the kidney in health and disease: Emphasis on the role of purinergic cotransmission
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.autneu.2016.05.007
Publisher version: http://dx.doi.org/10.1016/j.autneu.2016.05.007
Language: English
Additional information: © 2016 Elsevier B.V. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: ATP, Collecting duct, Diabetes, Hypertension, Noradrenaline, Renin
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1499768
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