UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Liver function as an engineering system

Ashworth, W; Perez-Galvan, C; Davies, N; Lockhart Bogle, ID; (2016) Liver function as an engineering system. AIChE Journal , 62 (9) pp. 3285-3297. 10.1002/aic.15292. Green open access


Download (795kB) | Preview


Process Systems Engineering has tackled a wide range of problems including manufacturing, the environment, and advanced materials design. Here we discuss how tools can be deployed to tackle medical problems which involve complex chemical transformations and spatial phenomena looking in particular at the liver system, the body's chemical factory. We show how an existing model has been developed to model distributed behavior necessary to predict the behavior of drugs for treating liver disease. The model has been used to predict the effects of suppression of de novo lipogenesis, stimulation of β-oxidation and a combination of the two. A reduced model has also been used to explore the prediction of behavior of hormones in the blood stream controlling glucose levels to ensure that levels are kept within safe bounds using interval methods. The predictions are made resulting from uncertainty in two key parameters with oscillating input resulting from regular feeding.

Type: Article
Title: Liver function as an engineering system
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/aic.15292
Publisher version: http://dx.doi.org/10.1002/aic.15292
Language: English
Additional information: Copyright © 2016 The Authors AIChE Journal published by Wiley Periodicals, Inc. on behalf of American Institute of Chemical Engineers. This is an open access article under the terms of the Creative Commons Attribution License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: mathematical modeling; biomedical engineering; systems biology; medical; control
URI: http://discovery.ucl.ac.uk/id/eprint/1497101
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item