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EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase

Gudkova, D; Panasyuk, G; Nemazanyy, I; Zhyvoloup, A; Monteil, P; Filonenko, V; Gout, I; (2012) EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase. FEBS Letters , 586 (20) pp. 3590-3595. 10.1016/j.febslet.2012.08.033. Gold open access

Abstract

Coenzyme A synthase (CoAsy) is a bifunctional enzyme which facilitates the last two steps of Coenzyme A biogenesis in higher eukaryotes. Here we describe that CoAsy forms a complex with enhancer of mRNA-decapping protein 4 (EDC4), a central scaffold component of processing bodies. CoAsy/EDC4 complex formation is regulated by growth factors and is affected by cellular stresses. EDC4 strongly inhibits the dephospho-CoA kinase activity of CoAsy in vitro. Transient overexpression of EDC4 decreases cell proliferation, and further co-expression of CoAsy diminishes this effect. Here we report that EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies.

Type: Article
Title: EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase
Open access status: An open access publication
DOI: 10.1016/j.febslet.2012.08.033
Publisher version: http://dx.doi.org/10.1016/j.febslet.2012.08.033
Language: English
Keywords: CoA synthase; CoA; Processing bodies; EDC4; Decapping; Mitochondria
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1497007
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