Kojima, G;
Taniguchi, Y;
Iliffe, S;
Walters, K;
(2016)
Frailty as a Predictor of Alzheimer Disease, Vascular Dementia, and All Dementia Among Community-Dwelling Older People: A Systematic Review and Meta-Analysis.
Journal of the American Medical Directors Association
, 17
(10)
pp. 881-888.
10.1016/j.jamda.2016.05.013.
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Kojima et al Frailty as a Predictor of Alzheimer’s Disease, Vascular Dementia, and All Dementia among Community-Dwelling Older People - A Systematic Review and Meta-analysis AAM.pdf Download (441kB) | Preview |
Abstract
OBJECTIVE: To perform a systematic search of the literature for currently available evidence on frailty as a predictor of dementia and to conduct a meta-analysis to synthesize the pooled risk estimates among community-dwelling older people. DESIGN: A systematic review and meta-analysis. DATA SOURCES: Embase, MEDLINE, CINAHL Plus, PsycINFO, and the Cochrane Library from 2000 to January 2016, and reference lists of relevant articles. ELIGIBILITY CRITERIA: Any studies that prospectively examined the incident risks of dementia with frailty among community-dwelling older people without language restriction. RESULTS: Of 2565 studies identified through the systematic review, 7 studies were included in this review. Of these, 4 studies reported hazard ratios (HR) of incident dementia for physical frailty defined by Cardiovascular Health Study criteria and were included in a meta-analysis. Frailty was a significant predictor of incident Alzheimer disease (4 studies: pooled HR = 1.28, 95% confidence interval (95% CI) = 1.00-1.63, P = .05), vascular dementia (2 studies: pooled HR 2.70, 95% CI 1.40-5.23, P = .003), and all dementia (3 studies: pooled HR 1.33, 95% CI 1.07-1.67, P = .01). Heterogeneity across the studies was low to modest (I(2) = 0%-51%). A random-effects meta-regression analysis showed that the female proportion of the cohort primarily mediated the association of frailty with Alzheimer disease (female proportion coefficient = 0.04, 95%CI = 0.01-0.08, P = .01). CONCLUSION: This systematic review and meta-analysis suggests that frailty was a significant predictor of Alzheimer disease, vascular dementia, and all dementia among community-dwelling older people. Frail women may have a higher risk of incident Alzheimer disease than frail men.
| Type: | Article |
|---|---|
| Title: | Frailty as a Predictor of Alzheimer Disease, Vascular Dementia, and All Dementia Among Community-Dwelling Older People: A Systematic Review and Meta-Analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jamda.2016.05.013 |
| Publisher version: | http://dx.doi.org/10.1016/j.jamda.2016.05.013 |
| Language: | English |
| Additional information: | Copyright © 2016 AMDA - The Society for Post-Acute and Long-Term Care Medicine. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | Frailty; dementia; Alzheimer disease; Community-dwelling older people |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1496819 |
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