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ErbB4 is a suppressor of long-term potentiation in the adult hippocampus.

Pitcher, GM; Beggs, S; Woo, R-S; Mei, L; Salter, MW; (2008) ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. Neuroreport , 19 (2) pp. 139-143. 10.1097/WNR.0b013e3282f3da10.

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Abstract

ErbB4 has emerged as a leading susceptibility gene for schizophrenia but the function of the ErbB4 receptor in the adult brain is unknown. Here, we show in the adult hippocampus that long-term potentiation (LTP) of transmission at Schaffer collateral CA1 synapses was markedly enhanced in mutant mice lacking ErbB4. Concordantly, LTP was enhanced by acutely blocking ErbB4 in wild-type animals, indicating that ErbB4 activity constitutively suppresses LTP. Moreover, increasing ErbB4 signaling further suppressed LTP. By contrast, altering ErbB4 activity did not affect basal synaptic transmission or short-term facilitation. Our findings suggest that cognitive deficits in schizophrenia may be a consequence of hyperfunction of ErbB4 signaling leading to suppressed glutamatergic synaptic plasticity, thus opening new approaches for the treatment of this disorder.

Type: Article
Title: ErbB4 is a suppressor of long-term potentiation in the adult hippocampus.
Location: England
DOI: 10.1097/WNR.0b013e3282f3da10
Keywords: Animals, Cognition Disorders, Down-Regulation, ErbB Receptors, Hippocampus, Long-Term Potentiation, Male, Mice, Mice, Knockout, Neural Pathways, Organ Culture Techniques, Rats, Rats, Sprague-Dawley, Receptor, ErbB-4, Schizophrenia, Synaptic Transmission, Theta Rhythm
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1496657
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