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Lessons from non-canonical splicing

Sibley, CR; Blazquez, L; Ule, J; (2016) Lessons from non-canonical splicing. Nature Reviews Genetics , 17 (7) pp. 407-421. 10.1038/nrg.2016.46. Green open access

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Abstract

Recent improvements in experimental and computational techniques that are used to study the transcriptome have enabled an unprecedented view of RNA processing, revealing many previously unknown non-canonical splicing events. This includes cryptic events located far from the currently annotated exons and unconventional splicing mechanisms that have important roles in regulating gene expression. These non-canonical splicing events are a major source of newly emerging transcripts during evolution, especially when they involve sequences derived from transposable elements. They are therefore under precise regulation and quality control, which minimizes their potential to disrupt gene expression. We explain how non-canonical splicing can lead to aberrant transcripts that cause many diseases, and also how it can be exploited for new therapeutic strategies.

Type: Article
Title: Lessons from non-canonical splicing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrg.2016.46
Publisher version: http://dx.doi.org/10.1038/nrg.2016.46
Language: English
Additional information: Copyright © 2016 Macmillan Publishers Limited. All rights reserved
Keywords: Alternative splicing; RNA splicing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1496220
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