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Pathophysiology of Cluster Headache: Current Status and Future Directions

Matharu, MS; Obermann, M; (2015) Pathophysiology of Cluster Headache: Current Status and Future Directions. In: Ashina, M and Geppetti, P, (eds.) Pathophysiology of Headaches From Molecule to Man. Springer: Switzerland.

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Abstract

Typical clinical features of cluster headache (CH) include trigeminal distribution of pain, circadian and circannual rhythmicity, and ipsilateral cranial autonomic features. The striking circadian and circannual periodicity led to the suggestion that the hypothalamus, which is the structure involved in the human biological clock system, plays a pivotal role in the pathophysiology of this disorder. Several studies using neuroimaging techniques or measuring hormone levels supported the hypothesis of a hypothalamic involvement. Animal studies added further evidence regarding this hypothesis. Based on previous data, even invasive treatment methods such as hypothalamic deep brain stimulation (DBS) were justified. More recent studies point towards a complex neural network performance deficit in CH with complex interactions and multiple influences that will have to be unravelled in the future

Type: Book chapter
Title: Pathophysiology of Cluster Headache: Current Status and Future Directions
ISBN: 3319156217
ISBN-13: 9783319156217
DOI: 10.1007/978-3-319-15621-7_13
Publisher version: https://www.springer.com/gp/book/9783319156200
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cluster headache.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/1495888
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