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Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system

Guo, W; Sui, QQ; Gao, XF; Feng, JF; Zhu, J; He, C; Knight, GE; ... Xiang, Z; + view all (2016) Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system. Purinergic Signalling , 12 (3) pp. 489-496. 10.1007/s11302-016-9515-6. Green open access

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Abstract

P2X2 receptors, with other P2X receptor subtypes, have an important role mediating synaptic transmission in regulating the functions of the gastrointestinal tract. Our recent work has found a new regulator of P2X receptor function, called phosphoinositide-interacting regulator of transient receptor potential channels (Pirt). In the present work, we have shown that Pirt immunoreactivity was localized in nerve cell bodies and nerve fibers in the myenteric plexus of the stomach, ileum, proximal, and distal colon and in the submucosal plexus of the jejunum, ileum, proximal, and distal colon. Almost all the Pirt-immunoreactive (ir) neurons were also P2X2-ir, and co-immunoprecipitation experiments have shown that Pirt co-precipitated with the anti-P2X2 antibody. This work provides detailed information about the expression of Pirt in the gut and its co-localization with P2X2, indicating its potential role in influencing P2X2 receptor function.

Type: Article
Title: Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11302-016-9515-6
Publisher version: http://doi.org/10.1007/s11302-016-9515-6
Language: English
Additional information: Copyright © Springer Science+Business Media Dordrecht 2016. The final publication is available at Springer via http://dx.doi.org/10.1007/s11302-016-9515-6
Keywords: Enteric nervous system, Mouse, P2X2 receptor, Pirt protein
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1495808
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