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Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.

Ferrer, IR; Wagener, ME; Robertson, JM; Turner, AP; Araki, K; Ahmed, R; Kirk, AD; ... Ford, ML; + view all (2010) Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. J Immunol , 185 (4) pp. 2004-2008. 10.4049/jimmunol.1001176.

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Abstract

Recent evidence demonstrating that exposure to rapamycin during viral infection increased the quantity and quality of Ag-specific T cells poses an intriguing paradox, because rapamycin is used in transplantation to dampen, rather than enhance, donor-reactive T cell responses. In this report, we compared the effects of rapamycin on the Ag-specific T cell response to a bacterial infection versus a transplant. Using a transgenic system in which the Ag and the responding T cell population were identical in both cases, we observed that treatment with rapamycin augmented the Ag-specific T cell response to a pathogen, whereas it failed to do so when the Ag was presented in the context of a transplant. These results suggest that the environment in which an Ag is presented alters the influence of rapamycin on Ag-specific T cell expansion and highlights a fundamental difference between Ag presented by an infectious agent as compared with an allograft.

Type: Article
Title: Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
Location: United States
DOI: 10.4049/jimmunol.1001176
Keywords: Adoptive Transfer, Animals, CD8-Positive T-Lymphocytes, Female, Flow Cytometry, Immunosuppressive Agents, Interferon-gamma, L-Selectin, Listeria monocytogenes, Listeriosis, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Sirolimus, Skin Transplantation, Spleen, T-Lymphocytes
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1495205
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