UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Non-signalling energy use in the developing rat brain

Engl, E; Jolivet, R; Hall, CN; Attwell, D; (2017) Non-signalling energy use in the developing rat brain. Journal of Cerebral Blood Flow & Metabolism , 37 (3) pp. 951-966. 10.1177/0271678X16648710. Green open access

[img]
Preview
Text
J Cereb Blood Flow Metab-2016-Engl-0271678X16648710.pdf - ["content_typename_Published version" not defined]

Download (828kB) | Preview

Abstract

Energy use in the brain constrains its information processing power, but only about half the brain's energy consumption is directly related to information processing. Evidence for which non-signalling processes consume the rest of the brain's energy has been scarce. For the first time, we investigated the energy use of the brain's main non-signalling tasks with a single method. After blocking each non-signalling process, we measured oxygen level changes in juvenile rat brain slices with an oxygen-sensing microelectrode and calculated changes in oxygen consumption throughout the slice using a modified diffusion equation. We found that the turnover of the actin and microtubule cytoskeleton, followed by lipid synthesis, are significant energy drains, contributing 25%, 22% and 18%, respectively, to the rate of oxygen consumption. In contrast, protein synthesis is energetically inexpensive. We assess how these estimates of energy expenditure relate to brain energy use in vivo, and how they might differ in the mature brain.

Type: Article
Title: Non-signalling energy use in the developing rat brain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0271678X16648710
Publisher version: http://dx.doi.org/10.1177/0271678X16648710
Language: English
Additional information: © Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: ATP, brain development, brain slice, energy metabolism, lipids
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1494613
Downloads since deposit
31Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item