UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Application of ultrasound-based computational fluid dynamics to modeling blood flow in the carotid bifurcation

Augst, AD; Ariff, B; Barratt, DC; Thom, SAM; Hughes, AD; Xu, XY; (2005) Application of ultrasound-based computational fluid dynamics to modeling blood flow in the carotid bifurcation. In: Medical Imaging Systems Technology: Volume 5: Methods in Cardiovascular and Brain Systems. (pp. 109-156).

Full text not available from this repository.

Abstract

© 2005 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. Atherosclerotic plaque formation has been linked to haemodynamic risk factors, such as low and oscillating wall shear stresses (WSS). Experimental and numerical methods have been developed to investigate the mechanisms involved. Computational fluid dynamics (CFD) methods have the advantages of low cost and easily manageable numerical results. In order to obtain physiologically realistic results, CFD can be linked with medical imaging methods, which allow the extraction of in vivo vascular geometry and flow data to be used as input for haemodynamic simulations. Most of the image-based CFD approaches have been based on MRI, which has the disadvantages of relatively high cost and limited availability. Hence, a novel technique based on 3D ultrasound was developed with the advantages of low cost, fast acquisition and high spatial resolution. A methodology was developed to extract geometric information from the ultrasound images, reconstruct the surfaces and generate computational grids for flow simulations of the human carotid artery bifurcation. Additionally, a scheme was devised to utilize Doppler flow information for CFD boundary conditions. Accuracy and reproducibility of the combined imaging and modeling approach were evaluated in vitro and in vivo and the developed protocol was applied to normal subjects. The main conclusion of this work is the feasibility of 3D and Doppler ultrasound based CFD simulations for clinical applications. However, there are several limitations when applying this methodology in carotid bifurcations, i.e. the location of the carotid bulb relative to the jaw bone, which obscures the ultrasound path when the bifurcation is high in the neck. Future work should focus on minimizing the limitations and improve automation and reliability of image processing and reconstruction.

Type: Book chapter
Title: Application of ultrasound-based computational fluid dynamics to modeling blood flow in the carotid bifurcation
ISBN-13: 9789812569899
DOI: 10.1142/9789812701046_0004
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/1494332
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item