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Threshold Photodynamic (Pdt) Effects For Experimental Coloniccolonic Photodynamic Therapy

(1989) Threshold Photodynamic (Pdt) Effects For Experimental Coloniccolonic Photodynamic Therapy. Proceedings of SPIE - The International Society for Optical Engineering , 1067 pp. 248-253. 10.1117/12.952129.

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Abstract

The Existence Of A Threshold Photodynamic Dose Has Been Postulated Because Of The Sharp Demarcation Between An Area Of Pdt Necrosis And Normal Undamaged Tissue1. An Experiment Was Designed To Measure The Light Intensity At Various Distances From The Source Of Irradiation During Pdt. Experiments Were Performed On Normal Rodent Colon Using A Standard Intravenously Injected Dose Of The Photosensitiser Aluminium Sulphonated Phthalocyanine (Alspc). Irradiation Was Performed 1 Hour After Injection Of 5Mgkg-L Using An Argon Pumped Dye Laser Delivering L00Mw From The End Of The Fibre. The Time Of Irradiation Was Varied And The Amount Of Necrosis Measured 72 Hours After Treatment. The Light Intensity At Specific Points Could Be Correlated With The Amount Of Necrosis. Threshold Photodynamic Effects Are Important, If A Total Photodynamic Dose (Light Fluence X Photosensitiser Concentration) Is Considered, Since Selective Tumour Destruction May Be Possible If The Dosimetry Is Carefully Adjusted To Allow A Photodynamic Thresholdto Be Reached In The Tumour And Not In The Normal Colon. Adjustment Of The Light Or Photosensitiser Dose Can Be Used To Manipulate The Effect. Under Apprpriate Circumstances Alspc Can Be Photodegraded So That A Total Threshold Photodynamic Dose May Never Be Reached In Normal Colon. © 1989 SPIE.

Type: Article
Title: Threshold Photodynamic (Pdt) Effects For Experimental Coloniccolonic Photodynamic Therapy
DOI: 10.1117/12.952129
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/1494219
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