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Comparing selection on S. aureus between antimicrobial peptides and common antibiotics.

Dobson, AJ; Purves, J; Kamysz, W; Rolff, J; (2013) Comparing selection on S. aureus between antimicrobial peptides and common antibiotics. PLoS One , 8 (10) , Article e76521. 10.1371/journal.pone.0076521.

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Abstract

With a diminishing number of effective antibiotics, there has been interest in developing antimicrobial peptides (AMPs) as drugs. However, any new drug faces potential bacterial resistance evolution. Here, we experimentally compare resistance evolution in Staphylococcus aureus selected by three AMPs (from mammals, amphibians and insects), a combination of two AMPs, and two antibiotics: the powerful last-resort vancomycin and the classic streptomycin. We find that resistance evolves readily against single AMPs and against streptomycin, with no detectable fitness cost. However the response to selection from our combination of AMPs led to extinction, in a fashion qualitatively similar to vancomycin. This is consistent with the hypothesis that simultaneous release of multiple AMPs during immune responses is a factor which constrains evolution of AMP resistant pathogens.

Type: Article
Title: Comparing selection on S. aureus between antimicrobial peptides and common antibiotics.
Location: United States
DOI: 10.1371/journal.pone.0076521
Keywords: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Drug Resistance, Bacterial, Humans, Inhibitory Concentration 50, Microbial Sensitivity Tests, Staphylococcal Infections, Staphylococcus aureus, Time Factors, Vancomycin
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1494177
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