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Identification of immunological expressed sequence tags in the mealworm beetle Tenebrio molitor.

Dobson, AJ; Johnston, PR; Vilcinskas, A; Rolff, J; (2012) Identification of immunological expressed sequence tags in the mealworm beetle Tenebrio molitor. J Insect Physiol , 58 (12) pp. 1556-1561. 10.1016/j.jinsphys.2012.09.009.

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Abstract

Understanding the evolutionary ecology of immune responses to persistent infection could provide fundamental insight into temporal dynamics or interactive mechanisms that could be co-opted for antibiotic treatment regimes. Additionally, identification of novel molecules involved in these processes could provide novel compounds for biotechnological development. The beetle Tenebrio molitor displays a high level of induced antimicrobial activity coincident with persistent immuno-resistant Staphylococcus aureus, and is the first invertebrate model for persistent infection. Here we present expressed sequence tags (ESTs) detected by suppression-subtraction hybridization of Tenebrio larvae after infection with S. aureus. Amongst others, we identified mRNAs coding for various oxidative enzymes and two antimicrobial peptides. These ESTs provide a foundation for mechanistic study of Tenebrio's immune system.

Type: Article
Title: Identification of immunological expressed sequence tags in the mealworm beetle Tenebrio molitor.
Location: England
DOI: 10.1016/j.jinsphys.2012.09.009
Keywords: Amino Acid Sequence, Animals, Antimicrobial Cationic Peptides, Coleoptera, Expressed Sequence Tags, Gene Library, Genes, Insect, Iron, Molecular Sequence Data, Nucleic Acid Hybridization, Polymerase Chain Reaction, Staphylococcus aureus
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1494174
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