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Future Prospects of 3D Human Chromosome Imaging by Serial Block Face Scanning Electron Microscopy

Yusuf, M; Chen, B; Robinson, I; (2016) Future Prospects of 3D Human Chromosome Imaging by Serial Block Face Scanning Electron Microscopy. Single Cell Biology , 05 (2) , Article 1000134. 10.4172/2168-9431.1000134. Green open access

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Abstract

The higher order structure of human chromosomes remains to be elucidated with the 30 nm mystery still remaining. For internal structure determination, transmission electron microscopy (TEM) cannot be used as the chromosomes are too thick (approx. 1.4 microns) and scanning electron microscopy (SEM) is a surface imaging technique. For this purpose, the three-dimensional (3D) serial block face scanning electron microscopy (SBFSEM) was used on imaging mitotic human chromosome for the first time.

Type: Article
Title: Future Prospects of 3D Human Chromosome Imaging by Serial Block Face Scanning Electron Microscopy
Open access status: An open access version is available from UCL Discovery
DOI: 10.4172/2168-9431.1000134
Publisher version: http://dx.doi.org/10.4172/2168-9431.1000134
Language: English
Additional information: Copyright: © 2016 Yusuf M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Chromosome; Serial block-face electron scanning microscopy; Three-dimensional imaging
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/1493337
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