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An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration

Burnstock, G; (2016) An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration. Neuropharmacology , 104 pp. 4-17. 10.1016/j.neuropharm.2015.05.031. Green open access

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Abstract

Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection and neuroregeneration. Initially there is a brief summary of the background of purinergic signalling, including release of purines and pyrimidines from neural and non-neural cells and their ectoenzymatic degradation, and the current characterisation of P1 (adenosine), and P2X (ion channel) and P2Y (G protein-coupled) nucleotide receptor subtypes. There is also coverage of the localization and roles of purinoceptors in the healthy central nervous system. The focus is then on the roles of purinergic signalling in trauma, ischaemia, stroke and in neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases, as well as multiple sclerosis and amyotrophic lateral sclerosis. Neuroprotective mechanisms involving purinergic signalling are considered and its involvement in neuroregeneration, including the role of adult neural stem/progenitor cells. This article is part of the Special Issue entitled 'Purines in Neurodegeneration and Neuroregeneration'.

Type: Article
Title: An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuropharm.2015.05.031
Publisher version: http://doi.org/10.1016/j.neuropharm.2015.05.031
Language: English
Additional information: © 2015 Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0.
Keywords: 2′- and 3′-O-(4-benzoylbenzoyl)-ATP (BzATP) (PubChem CID: 115205), ALS, ATP, ATP (PubChem CID: 5957), Adenosine (PubChem CID: 60961), Alzheimer's, Brilliant Blue G (BBG) (PubChem CID: 6328534), Diadenosine tetraphosphate (AP(4)A) (PubChem CID: 21706), Interleukin 1β (PubChem CID: 123872), MS, N-methyl-D-aspartate (NMDA) (PubChem CID: 22880), Parkinson's, Pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid (PPADS) (PubChem CID: 6093163), Stem cells, β-Amyloid(1–42) (PubChem CID: 57339251), γ-Amino butyric acid (GABA) (PubChem CID: 119)
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1490974
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