Gourine, A; Bondar, SI; Spyer, KM; Gourine, AV; (2008) Beneficial effect of the central nervous system beta-adrenoceptor blockade on the failing heart. CIRC RES , 102 (6) 633 - 636. 10.1161/CIRCRESAHA.107.165183.
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Heart failure patients are routinely given beta-adrenoceptor antagonists (beta-blockers), although the mechanism(s) underlying their beneficial effects is not fully resolved. It is not entirely clear how long-term application of negative inotropic compounds improves cardiac performance, slows remodeling processes, and decreases mortality. All beta-blockers, which produce a beneficial effect in heart failure, have in common a high degree of lipophilicity and, therefore, have the ability to cross the blood-brain barrier. Here, we show that blockade of beta-adrenoceptors directly in the brain (chronic intracerebroventricular administration of metoprolol) attenuates the progression of left ventricular remodeling in a rat model of myocardial infarction-induced heart failure. These results provide the first direct evidence that the action of certain beta-blockers in the brain could contribute to their beneficial effect on the failing heart.
|Title:||Beneficial effect of the central nervous system beta-adrenoceptor blockade on the failing heart|
|Keywords:||central nervous system, beta-blockers, heart failure, left ventricular remodeling, myocardial infarction, MYOCARDIAL-INFARCTION, FAILURE, MECHANISMS, TRIAL, RATS, DYSFUNCTION, METOPROLOL, BLOCKERS, DISEASE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Neuroscience, Physiology and Pharmacology|
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