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Tests for the statistical significance of protein sequence similarities in data-bank searches.

Mott, RF; Kirkwood, TB; Curnow, RN; (1990) Tests for the statistical significance of protein sequence similarities in data-bank searches. Protein Eng , 4 (2) pp. 149-154.

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Abstract

A suite of tests to evaluate the statistical significance of protein sequence similarities is developed for use in data bank searches. The tests are based on the Wilbur-Lipman word-search algorithm, and take into account the sequence lengths and compositions, and optionally the weighting of amino acid matches. The method is extended to allow for the existence of a sequence insertion/deletion within the region of similarity. The accuracy of statistical distributions underlying the tests is validated using randomly generated sequences and real sequences selected at random from the data banks. A computer program to perform the tests is briefly described.

Type: Article
Title: Tests for the statistical significance of protein sequence similarities in data-bank searches.
Location: England
Keywords: Algorithms, Amino Acid Sequence, Databases, Factual, Proteins, Sequence Homology, Nucleic Acid
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1487585
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