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A controlled family study of late-onset non-affective psychosis (late paraphrenia).

Howard, RJ; Graham, C; Sham, P; Dennehey, J; Castle, DJ; Levy, R; Murray, R; (1997) A controlled family study of late-onset non-affective psychosis (late paraphrenia). Br J Psychiatry , 170 pp. 511-514. 10.1192/bjp.170.6.511.

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Abstract

BACKGROUND: The relationship between those schizophrenia-like conditions that have their onset in late life and early-onset schizophrenia is unclear. Very few family history studies of patients with late-onset psychosis have been reported, and it is not known whether their relatives have an increased risk of psychosis. METHOD: Information was collected on the psychiatric morbidity of 269 first-degree relatives of patients with schizophrenia or delusional disorder with an onset after the age of 60 (late paraphrenia), and 272 first-degree relatives of healthy elderly control subjects, using a research diagnostic instrument. RESULTS: With a narrow age range (15-50 years) at risk, the estimated lifetime risk of schizophrenia was 1.3% in the relatives of both cases and controls. With a wider age range (15-90 years) at risk, estimated lifetime risk of schizophrenia was 2.3% for the relatives of cases and 2.2% for the relatives of controls. However, depression was significantly more common among the relatives of cases than controls. CONCLUSIONS: Those schizophrenia-like psychoses with onset in late life are not genetically associated with schizophrenia.

Type: Article
Title: A controlled family study of late-onset non-affective psychosis (late paraphrenia).
Location: England
DOI: 10.1192/bjp.170.6.511
Keywords: Adult, Age of Onset, Aged, Aged, 80 and over, Case-Control Studies, Delusions, Family Health, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pedigree, Psychotic Disorders, Schizophrenia
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/1487155
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