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Generic brain activation mapping in functional magnetic resonance imaging: a nonparametric approach.

Brammer, MJ; Bullmore, ET; Simmons, A; Williams, SC; Grasby, PM; Howard, RJ; Woodruff, PW; (1997) Generic brain activation mapping in functional magnetic resonance imaging: a nonparametric approach. Magn Reson Imaging , 15 (7) pp. 763-770.

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Abstract

We report a novel method to identify brain regions generically activated by periodic experimental design in functional magnetic resonance imaging data. This involves: 1) registering each of N individual functional magnetic resonance imaging datasets in a standard space; 2) computing the median standardised power of response to the experimental design; 3) testing median standardised power at each voxel against its nonparametrically ascertained distribution under the null hypothesis of no experimental effect; and 4) constructing a generic brain activation map. The method is validated by analysis of 6 null images, acquired under conditions when the null hypothesis was known to be true; 8 images acquired during periodic auditory-verbal stimulation; and 6 images acquired during periodic performance of a covert verbal fluency task.

Type: Article
Title: Generic brain activation mapping in functional magnetic resonance imaging: a nonparametric approach.
Location: Netherlands
Keywords: Acoustic Stimulation, Auditory Cortex, Brain, Brain Mapping, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Signal Processing, Computer-Assisted
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/1487154
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