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Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype.

Spender, LC; Cornish, GH; Sullivan, A; Farrell, PJ; (2002) Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype. J Virol , 76 (10) pp. 4919-4927. 10.1128/jvi.76.10.4919-4927.2002.

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Abstract

To identify cell proteins regulated by the Epstein-Barr virus (EBV) transcription factor EBNA-2, we analyzed a cell line with conditional EBNA-2 activity by using microarray expression profiling. This led to the identification of two novel target genes induced by EBNA-2. The first of these, interleukin-16, is an immunomodulatory cytokine involved in the regulation of CD4 T cells. The second, AML-2, is a member of the Runt domain family of transcription factors. Quiescent B cells initially expressed AML-1 but, 48 h after virus infection, the levels of AML-1 decreased dramatically, whereas the amount of AML-2 protein increased. Analysis of a panel of B-cell lines indicated that AML-2 expression is normally predominant in EBV latency III, whereas AML-1 is associated with EBV latency I or EBV-negative cells. The AML genes are the first example of cell transcription factors whose expression correlates with the latency I/III phenotype.

Type: Article
Title: Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype.
Location: United States
DOI: 10.1128/jvi.76.10.4919-4927.2002
Keywords: Adaptor Proteins, Signal Transducing, B-Lymphocytes, Burkitt Lymphoma, Carrier Proteins, Cell Line, Cell Transformation, Viral, Cells, Cultured, Core Binding Factor Alpha 2 Subunit, Core Binding Factor Alpha 3 Subunit, Cytoskeletal Proteins, DNA-Binding Proteins, Epstein-Barr Virus Nuclear Antigens, Gene Expression Profiling, Herpesvirus 4, Human, Humans, Interleukin-16, Intracellular Signaling Peptides and Proteins, LIM Domain Proteins, Lymphocyte Activation, Oligonucleotide Array Sequence Analysis, Phenotype, Proto-Oncogene Proteins, Transcription Factors, Tumor Cells, Cultured, Virus Latency
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1484733
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