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Organizers in Development

Anderson, C; Stern, CD; (2016) Organizers in Development. In: Current Topics in Developmental Biology: Essays on Developmental Biology, Part B. (pp. 435-454). Elsevier: Netherlands.

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Abstract

An "organizer" is formally defined as a region, or group of cells in an embryo that can both induce (change the fate) and pattern (generate an organized set of structures) adjacent embryonic cells. To date, about four such regions have been demonstrated: the primary or Spemann organizer (Hensen's node in amniotes), the notochord, the zone of polarizing activity of the limb bud, and the mid-hindbrain boundary. Here we review the evidence for these and compare them with a few other regions which have been proposed to represent other organizers and we speculate on why so few such regions have been discovered.

Type: Book chapter
Title: Organizers in Development
Location: United States
DOI: 10.1016/bs.ctdb.2015.11.023
Publisher version: http://dx.doi.org/10.1016/bs.ctdb.2015.11.023
Language: English
Keywords: Floor plate induction, Hensen's node, Neural induction, Notochord, Patterning, Primary organizer, Secondary organizers, Signaling, Spemann–Mangold organizer, Zone of polarizing activity
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1483471
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