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The contribution of gene-environment interaction to psychopathology.

Thapar, A; Harold, G; Rice, F; Langley, K; O'donovan, M; (2007) The contribution of gene-environment interaction to psychopathology. Dev Psychopathol , 19 (4) 989 - 1004. 10.1017/S0954579407000491.

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Abstract

The study of gene-environment interaction (G x E) constitutes an area of significant social and clinical significance. Different types of research study designs are being used to investigate the contribution of G x E to psychopathology, although the term G x E has also been used and interpreted in different ways. Despite mixed evidence that G x E contributes to psychopathology, some promising and consistent findings are emerging. Evidence is reviewed in relation to depression, antisocial behavior, schizophrenia, and attention-deficit/hyperactivity disorder. Although findings from various research designs have different meaning, interestingly much of the evidence with regard to the contribution of G x E that has arisen from twin and adoption studies has been for antisocial behavior and depression. It is for these same forms of psychopathology that molecular genetic evidence of G x E has also been most convincing. Finally, current and anticipated methodological challenges and implications for future research in this area are considered.

Type: Article
Title: The contribution of gene-environment interaction to psychopathology.
Location: United States
DOI: 10.1017/S0954579407000491
Publisher version: http://dx.doi.org/10.1017/S0954579407000491
Language: English
Keywords: Adoption, Adult, Antisocial Personality Disorder, Attention Deficit Disorder with Hyperactivity, Child, Depressive Disorder, Diseases in Twins, Genetic Predisposition to Disease, Humans, Mental Disorders, Risk Factors, Schizophrenia, Schizophrenic Psychology, Social Environment, Twin Studies as Topic
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/148347
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