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Membrane contact sites between pathogen-containing compartments and host organelles

Dumoux, M; Hayward, RD; (2016) Membrane contact sites between pathogen-containing compartments and host organelles. Biochimica et Biophysica Acta , 1861 pp. 895-899. 10.1016/j.bbalip.2016.01.018. Green open access

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Abstract

Intracellular pathogens survive and replicate within specialised membrane-bound compartments that can be considered as pseudo-organelles. Using the obligate intracellular bacterium Chlamydia as an illustrative example, we consider the modes of lipid transport between pathogen-containing compartments and host organelles, including the formation of static membrane contact sites. We discuss how lipid scavenging can be mediated via the reprogramming of cellular transporters at these interfaces and describe recent data suggesting that pathogen effectors modulate the formation of specific membrane contacts. Further study of these emerging mechanisms is likely to yield new insights into the cell biology of lipid transport and organelle communication, which highlights potential new targets and strategies for future therapeutics. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.

Type: Article
Title: Membrane contact sites between pathogen-containing compartments and host organelles
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbalip.2016.01.018
Publisher version: http://dx.doi.org/10.1016/j.bbalip.2016.01.018
Language: English
Additional information: © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Lipid, Membrane contact, Organelle, Pathogen, Type III secretion, Animals, Biological Transport, Cell Membrane, Chlamydia, Golgi Apparatus, Host-Pathogen Interactions, Humans, Inclusion Bodies, Organelles, Sphingomyelins
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1483373
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