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Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out

Eldholm, V; Balloux, F; (2016) Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out. Tends in Microbiology , 24 (8) pp. 637-648. 10.1016/j.tim.2016.03.007. Green open access

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Abstract

Antimicrobial resistance (AMR) threats are typically represented by bacteria capable of extensive horizontal gene transfer (HGT). One clear exception is Mycobacterium tuberculosis (Mtb). It is an obligate human pathogen with limited genetic diversity and a low mutation rate which lacks any evidence for HGT. Such features should, in principle, reduce its ability to rapidly evolve AMR. We identify key features in its biology and epidemiology that allow it to overcome its low adaptive potential. We focus in particular on its innate resistance to drugs, its unusual life cycle, including an often extensive latent phase, and its ability to shelter from exposure to antimicrobial drugs within cavities it induces in the lungs.

Type: Article
Title: Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tim.2016.03.007
Publisher version: http://doi.org/10.1016/j.tim.2016.03.007
Language: English
Additional information: © 2016 Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Microbiology, POST PRIMARY TUBERCULOSIS, DRUG-RESISTANCE, HIV-INFECTION, ANTIBIOTIC-RESISTANCE, GENOMIC ANALYSIS, LEPROSY PATIENTS, EVOLUTION, TRANSMISSION, MUTATION, ENGLAND
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1482492
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