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Dementia with Lewy bodies: A study of post-synaptic dopaminergic receptors with iodine-123 iodobenzamide single-photon emission tomography

Walker, Z; Costa, DC; Janssen, AG; Walker, RWH; Livingstone, G; Katona, CLE; (1997) Dementia with Lewy bodies: A study of post-synaptic dopaminergic receptors with iodine-123 iodobenzamide single-photon emission tomography. EUR J NUCL MED , 24 (6) 609 - 614.

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Abstract

Dementia with Lewy bodies (DLB) can at present only be diagnosed with certainty by neuropathological examination, Diagnosis during life remains at best probable, based on the presence of symptoms known from autopsy studies to be frequently associated with DLB. The greatest practical clinical problem lies in distinguishing DLB and Alzheimer's disease (AD), In DLB there is a considerable degeneration of nigral neurones with depletion of striatal dopamine, In contrast, AD is not associated with significant changes in dopamine metabolism, Iodine-123 iodobenzamide single-photon emission tomography (IBZM-SPET) measures post-synaptic dopamine D-2 neuroreceptor availability in the corpus striatum, but is nevertheless a method for assessing the integrity of the nigrostriatal dopaminergic pathway, Sixteen clinically diagnosed DLB patients, 15 normal controls and 13 AD patients underwent IBZM-SPET. All subjects were scanned 1.5-2 h after intravenous injection of 185 MBq of I-123-IBZM, Circular re regions of interest were employed to calculate radioactivity ratios in each hemisphere as follows: caudate nucleus/frontal cortex, putamen/frontal cortex and caudate nucleus/putamen, The DLB patients had significantly lower left caudate/putamen ratios (95% confidence intervals: DLB 0.893-0.965, AD 0.972-1.175, controls 1.031-1.168) than either controls or AD patients, and significantly lower right caudate/putamen ratios (95% confidence intervals: DLB 0.926-1.019, AD 0.954-1.103, controls 1.027-1.144) than controls. Our data suggest that patients with DLB diagnosed by clinical criteria have changes in striatal post-synaptic D-2 receptors, This may be of value in distinguishing DLB from AD during life.

Type: Article
Title: Dementia with Lewy bodies: A study of post-synaptic dopaminergic receptors with iodine-123 iodobenzamide single-photon emission tomography
Keywords: dementia with Lewy bodies, Alzheimer's disease, D-2 receptors, iodine-123 iodobenzamide, single-photon emission tomography, EARLY PARKINSONS-DISEASE, BODY DISEASE, CLINICAL-DIAGNOSIS, SENILE DEMENTIA, F-18 DOPA, IMMUNOCYTOCHEMISTRY, CRITERIA, I-123
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/148211
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