Yaldizli, Ö;
Sethi, V;
Pardini, M;
Tur, C;
Mok, KY;
Muhlert, N;
Liu, Z;
... Chard, DT; + view all
(2016)
HLA-DRB∗1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis.
Multiple Sclerosis and Related Disorders
, 7
pp. 47-52.
10.1016/j.msard.2016.03.003.
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Abstract
Background: The HLA-DRB∗1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim To assess HLA-DRB∗1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. / Methods: Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB∗1501 haplotype was determined by genotyping (rs3135388). / Results: No significant differences were observed in MRI measures between the HLA-DRB∗1501 subgroups. / Conclusions: The HLA-DRB∗1501 haplotype is not strongly associated with MRI-visible grey matter pathology.
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