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Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory

Hall, JH; Wiseman, FK; Fisher, EM; Tybulewicz, VL; Harwood, JL; Good, MA; (2016) Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory , 130 pp. 118-128. 10.1016/j.nlm.2016.02.002. Green open access

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Abstract

The present study examined memory function in Tc1 mice, a transchromosomic model of Down syndrome (DS). Tc1 mice demonstrated an unusual delay-dependent deficit in recognition memory. More specifically, Tc1 mice showed intact immediate (30sec), impaired short-term (10-min) and intact long-term (24-h) memory for objects. A similar pattern was observed for olfactory stimuli, confirming the generality of the pattern across sensory modalities. The specificity of the behavioural deficits in Tc1 mice was confirmed using APP overexpressing mice that showed the opposite pattern of object memory deficits. In contrast to object memory, Tc1 mice showed no deficit in either immediate or long-term memory for object-in-place information. Similarly, Tc1 mice showed no deficit in short-term memory for object-location information. The latter result indicates that Tc1 mice were able to detect and react to spatial novelty at the same delay interval that was sensitive to an object novelty recognition impairment. These results demonstrate (1) that novelty detection per se and (2) the encoding of visuo-spatial information was not disrupted in adult Tc1 mice. The authors conclude that the task specific nature of the short-term recognition memory deficit suggests that the trisomy of genes on human chromosome 21 in Tc1 mice impacts on (perirhinal) cortical systems supporting short-term object and olfactory recognition memory.

Type: Article
Title: Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.nlm.2016.02.002
Publisher version: http://dx.doi.org/10.1016/j.nlm.2016.02.002
Language: English
Additional information: Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/)
Keywords: Memory, Perirhinal, Recognition, Spatial, Tc1, Trisomy-21
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/1481048
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