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Slit-Robo interactions during cortical development

Andrews, WD; Barber, M; Parnavelas, JG; (2007) Slit-Robo interactions during cortical development. JOURNAL OF ANATOMY , 211 (2) 188 - 198. 10.1111/j.1469-7580.2007.00750.x. Gold open access

Abstract

Interneurons are an integral part of cortical neuronal circuits. During the past decade, numerous studies have shown that these cells, unlike their pyramidal counterparts that are derived from the neuroepithelium along the lumen of the lateral ventricles, are generated in the ganglionic eminences in the subpallium. They use tangential migratory paths to reach the cortex, guided by intrinsic and extrinsic cues. Evidence is now emerging which suggests that the family of Slit proteins, acting through Robo receptors, play a role not only in axon guidance in the developing forebrain, but also as guiding signals in the migration of cortical interneurons. Here we describe the patterns of expression of Slit and Robo at different stages of forebrain development and review the evidence in support of their role in cortical interneuron migration. Slit-Robo signal transduction mechanisms are also important during normal development in a number of systems in the body and in disease states, making them potential therapeutic targets for the treatment of neurological disorders and certain types of cancer.

Type: Article
Title: Slit-Robo interactions during cortical development
Location: Univ Complutense Madrid, Fac Med, Madrid, SPAIN
Open access status: An open access publication
DOI: 10.1111/j.1469-7580.2007.00750.x
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC23757...
Keywords: developing cortex, interneurons, neuronal migration, Robo, Slit, CONGENITAL DIAPHRAGMATIC-HERNIA, MEDIAL GANGLIONIC EMINENCE, TEMPORAL-LOBE EPILEPSY, CENTRAL-NERVOUS-SYSTEM, LONG-RANGE GUIDANCE, CELL-MIGRATION, AXON GUIDANCE, INTERNEURON MIGRATION, EXPRESSION PATTERNS, DIFFERENTIAL EXPRESSION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/148059
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