UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Patterns of regional cerebellar atrophy in genetic frontotemporal dementia

Bocchetta, M; Cardoso, MJ; Cash, DM; Ourselin, S; Warren, JD; Rohrer, JD; (2016) Patterns of regional cerebellar atrophy in genetic frontotemporal dementia. NeuroImage: Clinical , 11 pp. 287-290. 10.1016/j.nicl.2016.02.008. Green open access

Bocchetta_Patterns of regional cerebellar atrophy in genetic frontotemporal dementia.pdf

Download (752kB) | Preview


BACKGROUND: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder with a strong genetic component. The cerebellum has not traditionally been felt to be involved in FTD but recent research has suggested a potential role. METHODS: We investigated the volumetry of the cerebellum and its subregions in a cohort of 44 patients with genetic FTD (20 MAPT, 7 GRN, and 17 C9orf72 mutation carriers) compared with 18 cognitively normal controls. All groups were matched for age and gender. On volumetric T1-weighted magnetic resonance brain images we used an atlas propagation and label fusion strategy of the Diedrichsen cerebellar atlas to automatically extract subregions including the cerebellar lobules, the vermis and the deep nuclei. RESULTS: The global cerebellar volume was significantly smaller in C9orf72 carriers (mean (SD): 99989 (8939) mm(3)) compared with controls (108136 (7407) mm(3)). However, no significant differences were seen in the MAPT and GRN carriers compared with controls (104191 (6491) mm(3) and 107883 (6205) mm(3) respectively). Investigating the individual subregions, C9orf72 carriers had a significantly lower volume than controls in lobule VIIa-Crus I (15% smaller, p < 0.0005), whilst MAPT mutation carriers had a significantly lower vermal volume (10% smaller, p = 0.001) than controls. All cerebellar subregion volumes were preserved in GRN carriers compared with controls. CONCLUSION: There appears to be a differential pattern of cerebellar atrophy in the major genetic forms of FTD, being relatively spared in GRN, localized to the lobule VIIa-Crus I in the superior-posterior region of the cerebellum in C9orf72, the area connected via the thalamus to the prefrontal cortex and involved in cognitive function, and localized to the vermis in MAPT, the 'limbic cerebellum' involved in emotional processing.

Type: Article
Title: Patterns of regional cerebellar atrophy in genetic frontotemporal dementia
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.nicl.2016.02.008
Publisher version: http://dx.doi.org/10.1016/j.nicl.2016.02.008
Language: English
Additional information: Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: C9orf72, Cerebellum, Genetic frontotemporal dementia
URI: http://discovery.ucl.ac.uk/id/eprint/1478850
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item