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Chemistry-to-gene screens in Caenorhabditis elegans.

Jones, AK; Buckingham, SD; Sattelle, DB; (2005) Chemistry-to-gene screens in Caenorhabditis elegans. Nat Rev Drug Discov , 4 (4) pp. 321-330. 10.1038/nrd1692.

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Abstract

The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.

Type: Article
Title: Chemistry-to-gene screens in Caenorhabditis elegans.
Location: England
DOI: 10.1038/nrd1692
Keywords: Animals, Antinematodal Agents, Caenorhabditis elegans, Drug Design, Drug Resistance, Genes, Helminth, Models, Animal
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1478743
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