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Astrocyte calcium signaling: the third wave

Bazargani, N; Attwell, D; (2016) Astrocyte calcium signaling: the third wave. Nature Neuroscience , 19 (2) pp. 182-189. 10.1038/nn.4201. Green open access

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Abstract

The discovery that transient elevations of calcium concentration occur in astrocytes, and release 'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea that astrocytes are powerful regulators of neuronal spiking, synaptic plasticity and brain blood flow. These findings were challenged by a second wave of reports that astrocyte calcium transients did not mediate functions attributed to gliotransmitters and were too slow to generate blood flow increases. Remarkably, the tide has now turned again: the most important calcium transients occur in fine astrocyte processes not resolved in earlier studies, and new mechanisms have been discovered by which astrocyte [Ca(2+)]i is raised and exerts its effects. Here we review how this third wave of discoveries has changed our understanding of astrocyte calcium signaling and its consequences for neuronal function.

Type: Article
Title: Astrocyte calcium signaling: the third wave
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.4201
Publisher version: http://dx.doi.org/10.1038/nn.4201
Language: English
Additional information: Copyright © 2016 Nature America, Inc. All rights reserved. The published version of this article (Bazargani, N; Attwell, D; (2016) Astrocyte calcium signaling: the third wave. Nature Neuroscience , 19 (2) pp. 182-189. 10.1038/nn.4201) is available on the NPG website at http://dx.doi.org/10.1038/nn.4201
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1478400
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